Legionella pneumophila extensively modulates the host ubiquitin network to create the Legionella-containing vacuole (LCV) for its replication.Many of its virulence factors function File Cabinets as ubiquitin ligases or deubiquitinases (DUBs).Here, we identify Lem27 as a DUB that displays a preference for diubiquitin formed by K6, K11, or K48.Lem27
The hormone thyrotropin (TSH) and its receptor (TSHR) are crucial for the growth and function of the thyroid gland.The TSHR is evolutionary linked with the receptors of follitropin (FSHR) and lutropin/choriogonadotropin (LHR) and their sequences and structures are similar.The extracellular region of TSHR contains more than 350 amino acids and binds
Ice throw is a significant risk factor in the vicinity of wind turbines located in cold climate areas.We present a method to estimate the ice chunk trajectories.First, similar to the common practice, only translation is accounted Animated for and the object trajectory is determined by gravity and the aerodynamic drag force.The sensitivity of the tr